A Comparative Study on In-vitro Quality Control Parameters of Different Brands of Loratadine Tablets Commercially Available in Bangladesh

Loratadine, a second generation H1-receptor antagonist, works by blocking the action of histamine and is widely prescribed for itching, runny nose, watery eyes, sneezing from "hay fever" other allergic conditions. To ensure quality main requirements medicinal product are safety, potency, efficacy stability. This research work aimed to compare assess levels different local brands loratadine tablets available in drug market Bangladesh. Six 10 mg tablet manufactured companies were used analysis. The evaluation was performed through determination weight variation, hardness, friability, percent disintegration time, dissolution profile accordance with USP-NF specifications. All showed acceptable variation % friability. potency tested samples UV method ranges 97.02%-108%, showing none contains less than 90% active principle as per specification. result physical chemical studies, such in-vitro dissolution, disintegration, etc., has been found differ but lie within specified limit. After analyzing data obtained tests, it can be claimed that marketed several Bangladesh meet standard required achieve desired therapeutic outcomes.